CXL Experts’ Meeting 2017





Friday, December 1st, 2017



Chair: Eberhard Spoerl / Ahmed Elsheikh  
09.00 Fluence and corneal thickness Eberhard Spoerl (Germany)
09.20 CXL: Riboflavin, oxygen, light Sabine Kling (Switzerland)
09.40 Corneal structure and biomechanics Sally Hayes (UK)
10.00 Corneal Biomechanics: modulating factors Ahmed Elsheikh (UK)
10.20 Riboflavin absorption kinetics, enzymatic resistance David O’Brart (GB)
10.40 Corneal topography Mazen Sinjab (KSA)
11.00 Biomechanical changes after Cross-Linking Rohit Shetty (India)
11.20 Panel discussion
11.40–13.30 Lunch

CXL Protocols 1

Chair: Brad Randleman / Farhad Hafezi  
13.30 CorVis to measure biomechanics in vivo Paolo Vinciguerra (Italy)
13.50 Brillouin microscopy to measure biomechanics in vivo Brad Randleman (USA)
14.10 Keratoconus Frederik Raiskup (Germany)
14.30 Customized CXL Theo G. Seiler (Switzerland)
14.50 Panel discussion
15.40–15.40 Coffee break

CXL Protocols 2

Chair: Frederik Raiskup / Paolo Vinciguerra  
14.00 CXL/PRK and Xtra procedures A. John Kanellopoulos (USA)
14.20 PACK-CXL for corneal infections Emilio Torres (Switzerland)
14.40 CXL in very thin corneas Farhad Hafezi (Switzerland)
15.00 CXL as a refractive procedure Theo Seiler (Switzerland)
15.20 Panel discussion
15.40–16.00 End

Saturday, December 2nd, 2017



Chair: John Marshall / Rohit Shetty  
08.30 Effects of Drug Formulation, Supplemental Oxygen, and UV Delivery on Epi-On CXL Desmond ADLER
08.38 Novel chemical cross-linker for the cornea to treat keratoconus Rachel WILLIAMS
08.46 Brillouin Microscopy of Human Corneas Before and After Epi-On Cross-linking Doyle STULTING
08.54 Crosslinking of Kpro Corneal Carrier Donor Tissue to Prevent Keratolysis Joseph CIOLINO
09.10 Translational impact of Lysyl Oxidase (LOX) on cross-linking/refractive surgery and allied novel point-of-care diagnostic kit Pooja KHAMAR
09.18 Impact of Stromal Oxygen Dynamics on High-Irradiance Epi-On Crosslinking Desmond ADLER
09.26 Ocular Surface Immune Trafficking and Eye Rubbing in Keratoconus, and its impact on treatment outcomes Pavitra PATEL
09.34 Corneal UV-light crosslinking promotes high-risk corneal graft survival by regressing mature corneal lymphatic and blood vessels Claus CURSIEFEN
09.50 Safety of High-Dose, Transepithelial, Accelerated CXL with Supplemental Oxygen on Human and Monkey Eyes Jodhbir MEHTA
09.58 In vivo study of femtosecond laser crosslinking of corneal tissue to correct refractive errors Sinisa VUKELIC
10.06 Femtosecond laser induced corneal crosslinking towards correction of refractive errors – A parametric study Sinisa VUKELIC
10.20–10.50 Coffee Break


Chairs: J. Bradley Randleman/ Farhad Hafezi
10.50 Visual outcomes and graft survival rates of optical corneal transplants after Rose Bengal Photodynamic Antimicrobial Therapy Guillermo AMESCUA
10.58 Corneal endothelium and limbal stem cell niche following Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) Jean-Marie PAREL
11.06 PACK CXL as adjuvant treatment for acanthamoeba keratitis. A case study Mehrdad NATHEGI
11.14 Accelerated PACK-CXL as adjuvant treatment in infectious keratitis Boris KNAIZER

CXL Plus I

Chairs: Rohit Shetty / Efekan Coskunseven
11.30 An in situ UV polymerised artificial cornea for custom Smile surgery Ioannis PALLIKARIS
11.38 Topo-guided Removal of Epithelium in Keratoconus (TREK) and accelerated cross linking Sheetal MAHUVAKAR
11.46 Photorefractive keratectomy in patients with primary keratoconus after corneal collagen cross-linking Timur CHURAKOV
11.54 Combined epithelium-off topography-guided photorefractive keratectomy and corneal collagen cross-linking Miguel Mesquita NEVES
12.00-13.15 Lunch  



Chairs: Theo Seiler / Emilio Torres  
13.30 A novel method to study Bowman’s Layer Topography – A paradigm shift in understanding the corneal surface Natasha PAHUJA
13.38 Combined SMILE and CXL for Moderate to High Myopia in Patients with Thin or Steep Corneas Osama IBRAHIM
13.46 Complications of combined CXL and PRK Denise WAINSZTAJN VAMOS
13.54 Allograft lenticule onlay implantation with PRK after CXL in KC treatment Michael MROCHEN

CXL for keratoconus I

Chair: Paolo Vinciguerra / Riccardo Vinciguerra  
14.10 The independent effect of various treatment modalities on crosslinking effectiveness studied in 670 eyes Daniel GODEFROOIJ
14.18 Accelerated Versus Conventional Corneal Cross-Linking for Progressive Keratoconus: A Meta-Analysis of Randomized Controlled Trials Hidenaga KOBASHI
14.26 Assessment of association between in-vivo corneal biomechanical changes after CXL and depth of demarcation line Riccardo VINCIGUERRA
14.40 Is PMD a variant of Keratoconus or a different entity ? Ritika DALAL
14.48 Effects of corneal cross-linking on tensile properties of posterior and anterior corneal flaps Hamed HATAMI-MARBINI
14.56 Mega-dose dietary riboflavin and direct sunlight exposure in the treatment of KC and postoperative ectasia John JARSTADT
15.15 Congress Group Photo
15.40–16.10 Coffee Break

CXL for keratoconus II

Chair: Shihao Chen / Michael Belin  
16.10 Customized CXL for keratoconus – 3-year results Theo G. SEILER
16.18 Enhanced-Fluence Pulsed-Light Iontophoresis Corneal Cross Linking: 1-year morphological and clinical results Cosimo MAZZOTTA
16.26 Is corneal CXL treatment effective in stabilizing the corneal curvature during pregnancy in keratoconus patients? Ozge SARAC
16.45 Automated Detection and Classification of Corneal Haze using Optical Coherence Tomography in Keratoconus Eyes after Cross-linking Shady AWWAD
16.53 Athens Protocol After Femtosecond-Assisted Intracorneal Ring Implantation Bernardo LOPES
17.01 Corneal crosslinking (CXL) with two different riboflavin solutions. A randomized, controlled trial. Gerald SCHMIDINGER
17.10-17.30 CXL Experts Meeting Award Scientific Committee
17.35 Poster Award Scientific Committee
Closing remarks Farhad HAFEZI


1 Measuring Corneal Haze with OCT after Epithelial Disruption Corneal Collagen Cross-linking (CXL) with Trans-epithelial Riboflavin (TE) in patients with Keratoconus. Dhwni Shahanand
2 The analysis of early safety and stability after Corneal collagen cross-linking in keratoconus Wei Shengsheng
3 Transepithelial Versus Epithelium-off Corneal Cross-Linking for Progressive Corneal Ectasia: A Meta-Analysis of Randomized Controlled Trials Hidenaga Kobashi
4 Contact lens-assisted collagen cross-linking (CACXL). Elhaddi Mahfoudi
5 Simultaneous transepithelial Intra-tunnel cross linking with ICRS implantation versus simultaneous epi-off cross linking with ICRS implantation for keratoconus management Mohamed Hosny
6 Corneal Stability after Corneal Collagen Cross Linking in Early Adolescence Maja Bohac
7 The application of Transepithelial Phototerapeuthic Kerathectomy and Collagen Cross-linking in Pellucid Marginal Degeneration/PMD/ case report Beata Sawicka Wojtiuk
8 Long-term results of mechanical epithelial removal versus phototherapeutic keratectomy followed by accelerated corneal cross-linking for pediatric keratoconus Ozge Sarac
9 Intraoperative Corneal Thickness Changes during Pulsed Accelerated Corneal Cross-Linking Using Isotonic Riboflavin with HPMC Nihal Elghryany
10 Need of explantation of an intrastromal titan ring after penetrating keratoplasty in two patients with keratoconus Kassandra Xanthopoulou
11 K Readings, Corneal Thickness and Demarcation Line 3 Months After Accelerated Pulsed Corneal Cross Linking Nihal Elghryany
12 An artificial intelligence based customized crosslinking– A new dimension in keratoconus management Ritika Dalal
13 Distinguishing keratoconic eyes and healthy eyes using Ultrahigh-Resolution (UHR)-OCT based Corneal Epithelium Thickness Mapping Niklas Pircher
14 Decreased UV Light Filtering Ability of the Corneal Epithelium: Is it the Cause of Stromal Pathologies in Keratoconus Nurullah Cagil
15 Comparison of Outcomes with Standard and Accelerated Corneal Cross-linking Protocols in Patients with Progressive Keratoconus J. Bradley Randleman
16 Altered Epithelial Cells in Keratoconus : Implications in Crosslinking Sheetal Mahuvakar
17 Effectivenes of Accelerated Corneal Collagen Crosslinking for Keratoconus Patients : A Comparison of Two Protocols Reny Setyowati
18 Accelerated Corneal Collagen Cross Linking for Mild Keratoconus Suhardjo
19 Tomographic and refractive characteristics of pediatric first degree relatives of Keratoconus patients Shady Awwad
20 Effects of Iontophoresis – UVA cross-linking and hypotonic riboflavin solution on the ultrastructural architecture of human corneal stroma Saeed Akhtar
21 Biomechanical assessment of keratoconic eyes after corneal cross-linking by Scheimpflug-based tonometry Robert Herber
22 Comparative Analysis of Outcomes of Customised Topoguided Cross Linking versus conventional Cross Linking for progressive keratoconus Gitansha Sachdev
23 Stromal Demarcation Lines in Corneal Crosslinking (CXL): What We Know about Supplemental Oxygen Alexandra Nicklin

CXL in refractive laser surgery

24 Wide Area Surface Ablation Laser Guided by Corneal Wavefront Combined With Accelerated Cross-linking in the Treatment of Keratoconus Safwan Albayati
25 Pilot evaluation of photorefractive corneal collagen crosslinking for the treatment of low myopia: 6 month results Safa El Hout
26 Photorefractive intrastromal cross-linking (PiXL) for the treatment of low myopia Gitansha Sachdev
27 Epithelium-on Photorefractive Intrastromal Corneal Cross-linking (PiXL) with Supplemental Oxygen for the Treatment of Low Myopic Refractive Error: 6 Month Results of a Prospective Clinical Study Matthias Elling
28 Epithelial corneal mapping in keratoconus: to do or not to do? Mouhcine El Bakkali

PACK-CXL for infectious keratitis

29 The Effect of Accelerated Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking as Adjuvant Therapy on IL-6 Level of Corneal Ulcer Patient Suhardjo
30 Rose Bengal Photodynamic Antimicrobial Therapy as an Adjunct Treatment for Infectious Keratitis Jaime Martinez Martinez