Proceedings of the 2016 CXL Experts Meeting in Zurich, Switzerland

CXL Experts' Meeting 2016

Pictures

Basics

Chair:	Eberhard Spoerl / J. Bradley Randleman
09.00	Fluence and corneal thickness	Eberhard Spoerl (Germany)
09.20	Riboflavin, oxygen, and light	Sabine Kling (Switzerland)
09.40	Corneal Biomechanics	BJ Dupps (USA)
10.00	Smart patient selection	J. Bradley Randleman (USA)
10.20	Scheimpflug imaging for detecting ectasia, follow up and evaluating the results of CXL treatment	Fernando Faria Correia (Brazil)
10.40–11.00	Coffee break

CXL Protocols 1

Chair:	Frederik Raiskup / Theo Seiler
11.00	Keratoconus	Frederik Raiskup (Germany)
11.20	Structural changes after CXL	Cosimo Mazzotta (Italy)
11.40	Customized CXL	Theo G. Seiler (Switzerland)
12.00	Epi-on and epi-off applications	Carina Koppen (Belgium)
12.20	Panel discussion
12.30–14.00	Lunch

CXL Protocols 2

Chair:	A. John Kanellopoulos/ Carina Koppen
14.00	CXL Plus I	A. John Kanellopoulos (USA)
14.20	CXL Plus II	Theo Seiler (Switzerland)
14.40	Iontophoresis	Paolo Vinciguerra (Italy)
15.00	PACK-CXL for corneal infections	Farhad Hafezi (Switzerland)
15.20	CXL complication management	Paolo Vinciguerra (Italy)
15.40–16.00	Coffee Break

Company Courses

16.00	Schwind eye-tech solutions
16.30	EMAGine AG
17.00	LightforSight21
18.30	Congress Dinner

Les Bases et Protocoles

Chair:	Carina Koppen / Francois Malecaze
08.30	Les bases: fluence, illumination, profile d’irradiation	François Malecaze (France)
08.50	Riboflavine, oxygène, et lumière	Sabine Kling (Suisse)
09.10	Keratocône	François Malecaze (France)
09.30	Epi- on et epi-off	Carina Koppen (Belgique)
09.50	PACK-CXL pour les kératites inféctieuses	Farhad Hafezi (Suisse)

10.10 – 10.30	Pause Café

Les protocoles CXL vétérinaires / Veterinary CXL protocols

Chair:	Simon Pot / Jes Mortensen
10.30	Adapting CXL technology to veterinary ophthalmology	Simon Pot (Switzerland)
10.50	PACK-CXL for infectious keratitis in horses	Jes Mortensen (Sweden)
11.10	CXL acceleré pour la kératopathie bulleuse	Frank Famose (France)
11.30	Optimization du protocole PACK-CXL	Farhad Hafezi (Switzerland)
11.50	Les résultats cliniques I	Frank Famose (France)
12.10	Clinical results II	Simon Pot (Switzerland)
12.30-14.00	Lunch / Déjeuner

Saturday, December 3rd, 2016

CXL for ectasia: protocols

Chair:	Frederik Raiskup / Kevin Pierne
08.30	Pulsed CXL clinical study	Alireza Peyman (Iran) INVITED
08.40	Transepithelial Corneal Cross-linking Using an Enhanced Riboflavin Solution	Frederik Raiskup (Germany) INVITED
08.50	New transepithelial solution	David O’Brart (England) INVITED
09.00	Epi-on iontophoresis CXL. Latest clinical data	Paolo Vinciguerra (Italy) INVITED
09.10	Corneal Cross-Linking for Pediatric Keratoconus: Long-Term Results	Robert Wisse (The Netherlands) INVITED
09.20	Customized Corneal Crosslinking- One Year Results	Theo Günter Seiler (Switzerland) INVITED
09.30	New fluence nomogram to treat extremely thin KC corneas: theory	Sabine Kling (Switzerland) INVITED
09.40	New fluence nomogram to treat extremely thin KC corneas: clinical results	Farhad Hafezi (Switzerland) INVITED
09.50	Model-based prediction of crosslinking outcomes	BJ Dupps (USA) INVITED
10.00	Keratoconus Progression in Patients with Allergy and Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Vs Negative	Cosimo Mazzotta (Italy) INVITED
10.10–10.40	Coffee Break
10.40	Corneal Cross-linking for Progressive Keratoconus: Results of the US Phase III Clinical Study	Rajesh Rajpal (USA)
10.48	Customized topography-guided corneal cross-linking for keratoconus: clinical results	Kevin Pierne (France)
10.56	Accelerated versus Standard Corneal Collagen Cross-linking in Pediatric Keratoconus Patients: Two Year Follow-up Results	Ozge Sarac (Turkey)
11.04	Customized corneal crosslinking using different UVA beam profiles	Natasha Pahuja (India)
11.12	Accelerated corneal collagen cross-linking for keratoconus	Marcello Leucci (England)
11.20	Collagen cross-linked corneas assessment using multiphoton tomography	Karsten König (Germany)
11.28	Corneal Crosslinking (CXL) Without Removal of the Epithelium	Doyle Stulting (USA)
11.36	Discussion
12.00-13.15	Lunch

CXL for infectious keratitis (PACK-CXL)

Chair:	Boris Knaizer /Farhad Hafezi
13.15	First results of the PACK-CXL prospective multicenter trial	Farhad Hafezi (Switzerland) INVITED
13.25	Accelerated corneal cross-linking with photoactivated chromophore (PACK-CXL) for moderate therapy-resistant infectious keratitis	Boris Knaizer (Israel)
13.33	Evaluation of Corneal Cross-linking for Treatment of Fungal Keratitis: Using Confocal Laser Scanning Microscopy on an Ex-Vivo Human Corneal Model	Jawaher Alshehri (England)
13.41	Efficacy of Collagen Crosslinking in Bacterial Keratitis	Madhu Uddaraju (India)
13.49	Ultraviolet A/Riboflavin Collagen Cross-Linking for Treatment of Moderate Bacterial Corneal Ulcers	Shahram Bamdad (Iran)
14.00	Discussion
14.15–14.30	Congress Photoshoot

CXL Plus: combination procedures

Chair:	John Marshall / Theo G. Seiler
14.30	Biomechanics of PiXL	John Marshall (UK) INVITED
14.40	Interface bonding with corneal crosslinking after laser in situ keratomileusis (LASIK)	Theo G. Seiler (USA)
14.48	Post-LASIK ectasia: Understanding mechanistic pathway beyond topography	Kanchan Sainani (India)
14.56	Changes in Biomechanically corrected IOP and Dynamic Corneal Response Parameters Measured with the Corvis ST before and after laser vision surgery	David Sung Yong Kang (South Korea)
15.04	Customized Corneal Cross-Linking for the Treatment of Myopic Refractive Error: 6 Month Results of a Prospective Clinical Study	Matthias Elling (Germany)
15.12	Lasik Xtra: What is shown by the peer reviewed literature?	David Sung Yong Kang (South Korea)
15.20	Corneal Cross-linking for Corneal Ectasia following Refractive Surgery: Results of the US Phase III Clinical Study	Alexandra Nicklin (USA)
15.28	Discussion

15.45–16.15	Coffee Break

Current Controversies / New Approaches

Chair:	Theo Seiler / Sabine Kling
16.15	New Brillouin data	Theo Seiler (Switzerland) INVITED
16.25	Cross-Linking Biomechanical Effect in Human Corneas by Same Energy, Different UV-A Fluence: An Enzymatic Digestion Comparative Evaluation	A. John Kanellopoulos (Greece) INVITED
16.35	Enzymatic Resistance of Corneas Crosslinked Using Riboflavin in Conjunction With Low Energy, High Energy, and Pulsed UVA Irradiation Modes	Sally Hayes (UK) INVITED
16.45	Stress-strain measurements and hydration	Theo G. Seiler (Switzerland) INVITED
16.55	Influence of beam profile on changes of corneal topography and tomography after CXL in progressive keratoconus	Robert Herber (Germany)
17.03	The DUCK-score: A weighted compound score to improve decision making in crosslinking treatments.	Robert Wisse (Netherlands)
17.11	Brillouin Microscopic Imaging to Detect Biomechanical Changes after LASIK Combined with Rapid Corneal Cross-Linking	J. Bradley Randleman (USA)
17.19	Quantitative alterations in nerve morphology differentiate affected and unaffected eyes in unilateral Keratoconus	Pallak Kusumgar (India)
17.27	Comparison of corneal riboflavin gradients using dextran and HPMC solutions	Theo G. Seiler (USA)
17.35	Age-specific incidence and prevalence of keratoconus: a nationwide registration study	Daniel Godefrooij (Netherlands)
17.43	Long-term corneal biomechanical results and histology, 1, 4 and 8 months after WST-D and Near Infra-Red (NIR) treatment in rabbits	Jurriaan Brekelmans (Netherlands)
17.51	Long-Term Analysis of Collagen Crosslinking in Patients Treated with Dextran versus Hydroxypropyl Methylcellulose (HPMC) Riboflavin Solution	Patrick Rapuano (USA)
17.59	Flexible elastomer optical waveguide for whole-globe scleral crosslinking	Moonseok Kim (USA)
18.07	Differential gene expression of ECM-related genes after in vivo CXL in rabbits	Sabine Kling (Switzerland)
18.15	Correlation between central stromal demarcation line depth and flattening of the cornea after corneal cross-linking: comparing two different treatment protocols	Gerald Schmidinger (Austria)
18.23	The results of simultaneous on both eyes corneal collagen crosslinking	Timur Churakov (Russian Federation)
18.31	The Theo Seiler Award	Scientific Committee
18.36	Discussion
18.50	Final Remarks	Farhad Hafezi

Posters

Multiphoton tomography: a new imaging modality for corneal evaluation	Ana Batista (Germany)
The stability of the cornea after corneal cross-linking in pregnant women	Maja Bohac (Croatia)
Differential molecular signature in cone vs periphery and its impact on customised crosslinking	Natasha Pahuja (India)
Preliminary topographic results of accelerated pulsed light irradiation comparing with Dresden protocol	Nicolas Alejandre Alba (Spain)
Combined transepithelial photorefractive keratectomy and corneal collagen cross-linking for visual rehabilitation in moderate keratoconus	Vijaj Anand (England)
A case study: the flattening effect of epi-on cross-linking	Tetyana Tabalyuk (Ukraine)
Efficacy of pre-operative collagen cross linking (CXL) of human corneal transplants ex vivo: a pilot study	Gerald Schmidinger (Austria)
Next-generation corneal topography using high speed anterior segment OCT	Abhijit Sinha Roy (India)
Evaluation of topical therapeutic corneal tissue cross-linking using sodium hydroxymethylglycinate (SMG) by intravital confocal microscopy (HRT3) in the Dutch-belted rabbit	Mariya Zyablitskaya (USA)
Higher order optical aberrations and vision in a randomized controlled trial on transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus	Daniel Goodefrooij (Netherlands)
Cost-effectiveness of corneal crosslinking for progressive keratoconus	Daniel Goodefrooij (Netherlands)
Ocular Surface Disease Parameters after Corneal Cross-Linking for Keratoconus	Jose Ignacio Recalde (Spain)
Autorefraction versus subjective refraction in keratoconus patients	Nienke Soeters (Netherlands)
What are the costs of corneal crosslinking for the treatment of progressive keratoconus?	Daniel Goodefrooij (Netherlands)
Corneal transparency course after corneal collagen cross linking for keratoconus	Fanka Gilevska (Macedonia)
Regional variation of biomechanical properties in ectatic eyes	Daniela Oehring (England)
Corneal Imaging and Densitometry Measurements in Juvenile Keratoconus Patients to Monitor Disease Progression and Treatment Outcomes after Corneal Cross-Linking	Khaled Alzahrani (England)
Clinical progression parameters leading to a corneal crosslinking indication	Nayyirih de Koning-Tahzib (Netherlands)
The Biomechanical Properties of Rabbit Cornea at Different Corneal cross-linking irradiances	Shihao Chen (China)
Trans-Epithelium accelerated Corneal Collagen Cross-linking in Treating Primary Keratoconus with Different UVA Fluencies	Shihao Chen (China)

CXL Experts

KC Experts

KC Experts Poll Results

ACP

CXL Experts' Meeting 2016

Pictures

Friday, December 2nd, 2016

Basics

CXL Protocols 1

CXL Protocols 2

Company Courses

Les Bases et Protocoles

Les protocoles CXL vétérinaires / Veterinary CXL protocols

Saturday, December 3rd, 2016

CXL for ectasia: protocols

CXL for infectious keratitis (PACK-CXL)

CXL Plus: combination procedures

Current Controversies / New Approaches

Posters

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