CXL Experts' Meeting 2016

Friday, December 2nd, 2016


Chair:Eberhard Spoerl / J. Bradley Randleman 
09.00Fluence and corneal thicknessEberhard Spoerl (Germany)
09.20Riboflavin, oxygen, and lightSabine Kling (Switzerland)
09.40Corneal BiomechanicsBJ Dupps (USA)
10.00Smart patient selectionJ. Bradley Randleman (USA)
10.20Scheimpflug imaging for detecting ectasia, follow up and evaluating the results of CXL treatmentFernando Faria Correia (Brazil)
10.40–11.00Coffee break 


CXL Protocols 1

Chair:Frederik Raiskup / Theo Seiler 
11.00KeratoconusFrederik Raiskup (Germany)
11.20Structural changes after CXLCosimo Mazzotta (Italy)
11.40Customized CXLTheo G. Seiler (Switzerland)
12.00Epi-on and epi-off applicationsCarina Koppen (Belgium)
12.20Panel discussion 


CXL Protocols 2

Chair:A. John Kanellopoulos/ Carina Koppen 
14.00CXL Plus IA. John Kanellopoulos (USA)
14.20CXL Plus IITheo Seiler (Switzerland)
14.40IontophoresisPaolo Vinciguerra (Italy)
15.00PACK-CXL for corneal infectionsFarhad Hafezi (Switzerland)
15.20CXL complication managementPaolo Vinciguerra (Italy)
15.40–16.00Coffee Break 


Company Courses

16.00Schwind eye-tech solutions 
16.30EMAGine AG 
18.30Congress Dinner 


Les Bases et Protocoles

Chair:Carina Koppen / Francois Malecaze 
08.30Les bases: fluence, illumination, profile d’irradiationFrançois Malecaze (France)
08.50Riboflavine, oxygène, et lumièreSabine Kling (Suisse)
09.10KeratocôneFrançois Malecaze (France)
09.30Epi- on et epi-offCarina Koppen (Belgique)
09.50PACK-CXL pour les kératites inféctieusesFarhad Hafezi (Suisse)
10.10 – 10.30Pause Café 


Les protocoles CXL vétérinaires / Veterinary CXL protocols

Chair:Simon Pot / Jes Mortensen 
10.30Adapting CXL technology to veterinary ophthalmologySimon Pot (Switzerland)
10.50PACK-CXL for infectious keratitis in horsesJes Mortensen (Sweden)
11.10CXL acceleré pour la kératopathie bulleuseFrank Famose (France)
11.30Optimization du protocole PACK-CXLFarhad Hafezi (Switzerland)
11.50Les résultats cliniques I Frank Famose (France)
12.10Clinical results II Simon Pot (Switzerland)
12.30-14.00 Lunch / Déjeuner 


Saturday, December 3rd, 2016

CXL for ectasia: protocols

Chair:Frederik Raiskup / Kevin Pierne 
08.30Pulsed CXL clinical studyAlireza Peyman (Iran) INVITED
08.40Transepithelial Corneal Cross-linking Using an Enhanced Riboflavin SolutionFrederik Raiskup (Germany) INVITED
08.50New transepithelial solutionDavid O’Brart (England) INVITED
09.00Epi-on iontophoresis CXL. Latest clinical dataPaolo Vinciguerra (Italy) INVITED
09.10Corneal Cross-Linking for Pediatric Keratoconus: Long-Term ResultsRobert Wisse (The Netherlands) INVITED
09.20Customized Corneal Crosslinking- One Year ResultsTheo Günter Seiler (Switzerland) INVITED
09.30New fluence nomogram to treat extremely thin KC corneas: theorySabine Kling (Switzerland) INVITED
09.40New fluence nomogram to treat extremely thin KC corneas: clinical resultsFarhad Hafezi (Switzerland) INVITED
09.50Model-based prediction of crosslinking outcomesBJ Dupps (USA) INVITED
10.00Keratoconus Progression in Patients with Allergy and Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Vs NegativeCosimo Mazzotta (Italy) INVITED
10.10–10.40Coffee Break 
10.40Corneal Cross-linking for Progressive Keratoconus: Results of the US Phase III Clinical StudyRajesh Rajpal (USA)
10.48Customized topography-guided corneal cross-linking for keratoconus: clinical resultsKevin Pierne (France)
10.56Accelerated versus Standard Corneal Collagen Cross-linking in Pediatric Keratoconus Patients: Two Year Follow-up ResultsOzge Sarac (Turkey)
11.04Customized corneal crosslinking using different UVA beam profilesNatasha Pahuja (India)
11.12Accelerated corneal collagen cross-linking for keratoconusMarcello Leucci (England)
11.20Collagen cross-linked corneas assessment using multiphoton tomographyKarsten König (Germany)
11.28Corneal Crosslinking (CXL) Without Removal of the EpitheliumDoyle Stulting (USA)


CXL for infectious keratitis (PACK-CXL)

Chair:Boris Knaizer /Farhad Hafezi 
13.15First results of the PACK-CXL prospective multicenter trialFarhad Hafezi (Switzerland) INVITED
13.25Accelerated corneal cross-linking with photoactivated chromophore (PACK-CXL) for moderate therapy-resistant infectious keratitisBoris Knaizer (Israel)
13.33Evaluation of Corneal Cross-linking for Treatment of Fungal Keratitis: Using Confocal Laser Scanning Microscopy on an Ex-Vivo Human Corneal ModelJawaher Alshehri (England)
13.41Efficacy of Collagen Crosslinking in Bacterial KeratitisMadhu Uddaraju (India)
13.49Ultraviolet A/Riboflavin Collagen Cross-Linking for Treatment of Moderate Bacterial Corneal UlcersShahram Bamdad (Iran)
14.15–14.30Congress Photoshoot 


CXL Plus: combination procedures

Chair:John Marshall / Theo G. Seiler 
14.30Biomechanics of PiXL John Marshall (UK) INVITED
14.40Interface bonding with corneal crosslinking after laser in situ keratomileusis (LASIK)Theo G. Seiler (USA)
14.48Post-LASIK ectasia: Understanding mechanistic pathway beyond topographyKanchan Sainani (India)
14.56Changes in Biomechanically corrected IOP and Dynamic Corneal Response Parameters Measured with the Corvis ST before and after laser vision surgeryDavid Sung Yong Kang (South Korea)
15.04Customized Corneal Cross-Linking for the Treatment of Myopic Refractive Error: 6 Month Results of a Prospective Clinical StudyMatthias Elling (Germany)
15.12Lasik Xtra: What is shown by the peer reviewed literature?David Sung Yong Kang (South Korea)
15.20Corneal Cross-linking for Corneal Ectasia following Refractive Surgery: Results of the US Phase III Clinical StudyAlexandra Nicklin (USA)
15.45–16.15Coffee Break 


Current Controversies / New Approaches

Chair:Theo Seiler / Sabine Kling 
16.15New Brillouin dataTheo Seiler (Switzerland) INVITED
16.25Cross-Linking Biomechanical Effect in Human Corneas by Same Energy, Different UV-A Fluence: An Enzymatic Digestion Comparative EvaluationA. John Kanellopoulos (Greece) INVITED
16.35Enzymatic Resistance of Corneas Crosslinked Using Riboflavin in Conjunction With Low Energy, High Energy, and Pulsed UVA Irradiation ModesSally Hayes (UK) INVITED
16.45Stress-strain measurements and hydrationTheo G. Seiler (Switzerland) INVITED
16.55Influence of beam profile on changes of corneal topography and tomography after CXL in progressive keratoconusRobert Herber (Germany)
17.03The DUCK-score: A weighted compound score to improve decision making in crosslinking treatments.Robert Wisse (Netherlands)
17.11Brillouin Microscopic Imaging to Detect Biomechanical Changes after LASIK Combined with Rapid Corneal Cross-LinkingJ. Bradley Randleman (USA)
17.19Quantitative alterations in nerve morphology differentiate affected and unaffected eyes in unilateral KeratoconusPallak Kusumgar (India)
17.27Comparison of corneal riboflavin gradients using dextran and HPMC solutionsTheo G. Seiler (USA)
17.35Age-specific incidence and prevalence of keratoconus: a nationwide registration studyDaniel Godefrooij (Netherlands)
17.43Long-term corneal biomechanical results and histology, 1, 4 and 8 months after WST-D and Near Infra-Red (NIR) treatment in rabbitsJurriaan Brekelmans (Netherlands)
17.51Long-Term Analysis of Collagen Crosslinking in Patients Treated with Dextran versus Hydroxypropyl Methylcellulose (HPMC) Riboflavin SolutionPatrick Rapuano (USA)
17.59Flexible elastomer optical waveguide for whole-globe scleral crosslinkingMoonseok Kim (USA)
18.07Differential gene expression of ECM-related genes after in vivo CXL in rabbitsSabine Kling (Switzerland)
18.15Correlation between central stromal demarcation line depth and flattening of the cornea after corneal cross-linking: comparing two different treatment protocolsGerald Schmidinger (Austria)
18.23The results of simultaneous on both eyes corneal collagen crosslinkingTimur Churakov (Russian Federation)
18.31The Theo Seiler Award Scientific Committee
18.50Final RemarksFarhad Hafezi



Multiphoton tomography: a new imaging modality for corneal evaluationAna Batista (Germany)
The stability of the cornea after corneal cross-linking in pregnant womenMaja Bohac (Croatia)
Differential molecular signature in cone vs periphery and its impact on customised crosslinkingNatasha Pahuja (India)
Preliminary topographic results of accelerated pulsed light irradiation comparing with Dresden protocolNicolas Alejandre Alba (Spain)
Combined transepithelial photorefractive keratectomy and corneal collagen cross-linking for visual rehabilitation in moderate keratoconusVijaj Anand (England)
 A case study: the flattening effect of epi-on cross-linkingTetyana Tabalyuk (Ukraine)
Efficacy of pre-operative collagen cross linking (CXL) of human corneal transplants ex vivo: a pilot studyGerald Schmidinger (Austria)
Next-generation corneal topography using high speed anterior segment OCTAbhijit Sinha Roy (India)
Evaluation of topical therapeutic corneal tissue cross-linking using sodium hydroxymethylglycinate (SMG) by intravital confocal microscopy (HRT3) in the Dutch-belted rabbitMariya Zyablitskaya (USA)
Higher order optical aberrations and vision in a randomized controlled trial on transepithelial versus epithelium-off corneal crosslinking for progressive keratoconusDaniel Goodefrooij (Netherlands)
Cost-effectiveness of corneal crosslinking for progressive keratoconusDaniel Goodefrooij (Netherlands)
Ocular Surface Disease Parameters after Corneal Cross-Linking for KeratoconusJose Ignacio Recalde (Spain)
Autorefraction versus subjective refraction in keratoconus patientsNienke Soeters (Netherlands)
What are the costs of corneal crosslinking for the treatment of progressive keratoconus?Daniel Goodefrooij (Netherlands)
Corneal transparency course after corneal collagen cross linking for keratoconusFanka Gilevska (Macedonia)
Regional variation of biomechanical properties in ectatic eyesDaniela Oehring (England)
Corneal Imaging and Densitometry Measurements in Juvenile Keratoconus Patients to Monitor Disease Progression and Treatment Outcomes after Corneal Cross-LinkingKhaled Alzahrani (England)
Clinical progression parameters leading to a corneal crosslinking indicationNayyirih de Koning-Tahzib (Netherlands)

The Biomechanical Properties of Rabbit Cornea at Different Corneal cross-linking irradiances

Shihao Chen (China)

Trans-Epithelium accelerated Corneal Collagen Cross-linking in Treating Primary Keratoconus with Different UVA Fluencies

Shihao Chen (China)