CXL Experts’ Meeting 2016





Friday, December 2nd, 2016



Chair: Eberhard Spoerl / J. Bradley Randleman  
09.00 Fluence and corneal thickness Eberhard Spoerl (Germany)
09.20 Riboflavin, oxygen, and light Sabine Kling (Switzerland)
09.40 Corneal Biomechanics BJ Dupps (USA)
10.00 Smart patient selection J. Bradley Randleman (USA)
10.20 Scheimpflug imaging for detecting ectasia, follow up and evaluating the results of CXL treatment Fernando Faria Correia (Brazil)
10.40–11.00 Coffee break

CXL Protocols 1

Chair: Frederik Raiskup / Theo Seiler  
11.00 Keratoconus Frederik Raiskup (Germany)
11.20 Structural changes after CXL Cosimo Mazzotta (Italy)
11.40 Customized CXL Theo G. Seiler (Switzerland)
12.00 Epi-on and epi-off applications Carina Koppen (Belgium)
12.20 Panel discussion
12.30–14.00 Lunch

CXL Protocols 2

Chair: A. John Kanellopoulos/ Carina Koppen  
14.00 CXL Plus I A. John Kanellopoulos (USA)
14.20 CXL Plus II Theo Seiler (Switzerland)
14.40 Iontophoresis Paolo Vinciguerra (Italy)
15.00 PACK-CXL for corneal infections Farhad Hafezi (Switzerland)
15.20 CXL complication management Paolo Vinciguerra (Italy)
15.40–16.00 Coffee Break

Company Courses

16.00 Schwind eye-tech solutions
16.30 EMAGine AG
17.00 LightforSight21
18.30 Congress Dinner

Les Bases et Protocoles

Chair: Carina Koppen / Francois Malecaze
08.30 Les bases: fluence, illumination, profile d’irradiation François Malecaze (France)
08.50 Riboflavine, oxygène, et lumière Sabine Kling (Suisse)
09.10 Keratocône François Malecaze (France)
09.30 Epi- on et epi-off Carina Koppen (Belgique)
09.50 PACK-CXL pour les kératites inféctieuses Farhad Hafezi (Suisse)
10.10 – 10.30 Pause Café

Les protocoles CXL vétérinaires / Veterinary CXL protocols

Chair: Simon Pot / Jes Mortensen  
10.30 Adapting CXL technology to veterinary ophthalmology Simon Pot (Switzerland)
10.50 PACK-CXL for infectious keratitis in horses Jes Mortensen (Sweden)
11.10 CXL acceleré pour la kératopathie bulleuse Frank Famose (France)
11.30 Optimization du protocole PACK-CXL Farhad Hafezi (Switzerland)
11.50 Les résultats cliniques I  Frank Famose (France)
12.10 Clinical results II  Simon Pot (Switzerland)
12.30-14.00  Lunch / Déjeuner  

Saturday, December 3rd, 2016


CXL for ectasia: protocols

Chair: Frederik Raiskup / Kevin Pierne  
08.30 Pulsed CXL clinical study Alireza Peyman (Iran) INVITED
08.40 Transepithelial Corneal Cross-linking Using an Enhanced Riboflavin Solution Frederik Raiskup (Germany) INVITED
08.50 New transepithelial solution David O’Brart (England) INVITED
09.00 Epi-on iontophoresis CXL. Latest clinical data Paolo Vinciguerra (Italy) INVITED
09.10 Corneal Cross-Linking for Pediatric Keratoconus: Long-Term Results Robert Wisse (The Netherlands) INVITED
09.20 Customized Corneal Crosslinking- One Year Results Theo Günter Seiler (Switzerland) INVITED
09.30 New fluence nomogram to treat extremely thin KC corneas: theory Sabine Kling (Switzerland) INVITED
09.40 New fluence nomogram to treat extremely thin KC corneas: clinical results Farhad Hafezi (Switzerland) INVITED
09.50 Model-based prediction of crosslinking outcomes BJ Dupps (USA) INVITED
10.00 Keratoconus Progression in Patients with Allergy and Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test Vs Negative Cosimo Mazzotta (Italy) INVITED
10.10–10.40 Coffee Break
10.40 Corneal Cross-linking for Progressive Keratoconus: Results of the US Phase III Clinical Study Rajesh Rajpal (USA)
10.48 Customized topography-guided corneal cross-linking for keratoconus: clinical results Kevin Pierne (France)
10.56 Accelerated versus Standard Corneal Collagen Cross-linking in Pediatric Keratoconus Patients: Two Year Follow-up Results Ozge Sarac (Turkey)
11.04 Customized corneal crosslinking using different UVA beam profiles Natasha Pahuja (India)
11.12 Accelerated corneal collagen cross-linking for keratoconus Marcello Leucci (England)
11.20 Collagen cross-linked corneas assessment using multiphoton tomography Karsten König (Germany)
11.28 Corneal Crosslinking (CXL) Without Removal of the Epithelium Doyle Stulting (USA)
11.36 Discussion
12.00-13.15 Lunch  


CXL Plus: combination procedures

Chair: John Marshall / Theo G. Seiler  
14.30 Biomechanics of PiXL  John Marshall (UK) INVITED
14.40 Interface bonding with corneal crosslinking after laser in situ keratomileusis (LASIK) Theo G. Seiler (USA)
14.48 Post-LASIK ectasia: Understanding mechanistic pathway beyond topography Kanchan Sainani (India)
14.56 Changes in Biomechanically corrected IOP and Dynamic Corneal Response Parameters Measured with the Corvis ST before and after laser vision surgery David Sung Yong Kang (South Korea)
15.04 Customized Corneal Cross-Linking for the Treatment of Myopic Refractive Error: 6 Month Results of a Prospective Clinical Study Matthias Elling (Germany)
15.12 Lasik Xtra: What is shown by the peer reviewed literature? David Sung Yong Kang (South Korea)
15.20 Corneal Cross-linking for Corneal Ectasia following Refractive Surgery: Results of the US Phase III Clinical Study Alexandra Nicklin (USA)
15.28 Discussion
15.45–16.15 Coffee Break

Current Controversies / New Approaches

Chair: Theo Seiler / Sabine Kling  
16.15 New Brillouin data Theo Seiler (Switzerland) INVITED
16.25 Cross-Linking Biomechanical Effect in Human Corneas by Same Energy, Different UV-A Fluence: An Enzymatic Digestion Comparative Evaluation A. John Kanellopoulos (Greece) INVITED
16.35 Enzymatic Resistance of Corneas Crosslinked Using Riboflavin in Conjunction With Low Energy, High Energy, and Pulsed UVA Irradiation Modes Sally Hayes (UK) INVITED
16.45 Stress-strain measurements and hydration Theo G. Seiler (Switzerland) INVITED
16.55 Influence of beam profile on changes of corneal topography and tomography after CXL in progressive keratoconus Robert Herber (Germany)
17.03 The DUCK-score: A weighted compound score to improve decision making in crosslinking treatments. Robert Wisse (Netherlands)
17.11 Brillouin Microscopic Imaging to Detect Biomechanical Changes after LASIK Combined with Rapid Corneal Cross-Linking J. Bradley Randleman (USA)
17.19 Quantitative alterations in nerve morphology differentiate affected and unaffected eyes in unilateral Keratoconus Pallak Kusumgar (India)
17.27 Comparison of corneal riboflavin gradients using dextran and HPMC solutions Theo G. Seiler (USA)
17.35 Age-specific incidence and prevalence of keratoconus: a nationwide registration study Daniel Godefrooij (Netherlands)
17.43 Long-term corneal biomechanical results and histology, 1, 4 and 8 months after WST-D and Near Infra-Red (NIR) treatment in rabbits Jurriaan Brekelmans (Netherlands)
17.51 Long-Term Analysis of Collagen Crosslinking in Patients Treated with Dextran versus Hydroxypropyl Methylcellulose (HPMC) Riboflavin Solution Patrick Rapuano (USA)
17.59 Flexible elastomer optical waveguide for whole-globe scleral crosslinking Moonseok Kim (USA)
18.07 Differential gene expression of ECM-related genes after in vivo CXL in rabbits Sabine Kling (Switzerland)
18.15 Correlation between central stromal demarcation line depth and flattening of the cornea after corneal cross-linking: comparing two different treatment protocols Gerald Schmidinger (Austria)
18.23 The results of simultaneous on both eyes corneal collagen crosslinking Timur Churakov (Russian Federation)
18.31 The Theo Seiler Award  Scientific Committee
18.36 Discussion
18.50 Final Remarks Farhad Hafezi


Multiphoton tomography: a new imaging modality for corneal evaluation Ana Batista (Germany)
The stability of the cornea after corneal cross-linking in pregnant women Maja Bohac (Croatia)
Differential molecular signature in cone vs periphery and its impact on customised crosslinking Natasha Pahuja (India)
Preliminary topographic results of accelerated pulsed light irradiation comparing with Dresden protocol Nicolas Alejandre Alba (Spain)
Combined transepithelial photorefractive keratectomy and corneal collagen cross-linking for visual rehabilitation in moderate keratoconus Vijaj Anand (England)
 A case study: the flattening effect of epi-on cross-linking Tetyana Tabalyuk (Ukraine)
Efficacy of pre-operative collagen cross linking (CXL) of human corneal transplants ex vivo: a pilot study Gerald Schmidinger (Austria)
Next-generation corneal topography using high speed anterior segment OCT Abhijit Sinha Roy (India)
Evaluation of topical therapeutic corneal tissue cross-linking using sodium hydroxymethylglycinate (SMG) by intravital confocal microscopy (HRT3) in the Dutch-belted rabbit Mariya Zyablitskaya (USA)
Higher order optical aberrations and vision in a randomized controlled trial on transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus Daniel Goodefrooij (Netherlands)
Cost-effectiveness of corneal crosslinking for progressive keratoconus Daniel Goodefrooij (Netherlands)
Ocular Surface Disease Parameters after Corneal Cross-Linking for Keratoconus Jose Ignacio Recalde (Spain)
Autorefraction versus subjective refraction in keratoconus patients Nienke Soeters (Netherlands)
What are the costs of corneal crosslinking for the treatment of progressive keratoconus? Daniel Goodefrooij (Netherlands)
Corneal transparency course after corneal collagen cross linking for keratoconus Fanka Gilevska (Macedonia)
Regional variation of biomechanical properties in ectatic eyes Daniela Oehring (England)
Corneal Imaging and Densitometry Measurements in Juvenile Keratoconus Patients to Monitor Disease Progression and Treatment Outcomes after Corneal Cross-Linking Khaled Alzahrani (England)
Clinical progression parameters leading to a corneal crosslinking indication Nayyirih de Koning-Tahzib (Netherlands)

The Biomechanical Properties of Rabbit Cornea at Different Corneal cross-linking irradiances

Shihao Chen (China)

Trans-Epithelium accelerated Corneal Collagen Cross-linking in Treating Primary Keratoconus with Different UVA Fluencies

Shihao Chen (China)